STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Isop_1528Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0369 Sulfite reductase alpha subunit (flavoprotein); InterProIPR017927: IPR001709: IPR012146: IPR008333: IPR 001433; KEGG: gvi:gvip312 ferredoxin--NADP+ reductase; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: Ferredoxin--NADP+ reductase; manually curated; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain. (335 aa)    
Predicted Functional Partners:
Isop_1056
COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117: IPR006067: IPR006066; KEGG: psl:Psta_1330 sulfite reductase (NADPH); PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; PRIAM: Sulfite reductase (NADPH); SPTR: Sulfite reductase; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: ferredoxin-sulfite reductase.
 
 
 0.977
cysC
Sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
  
  
 0.954
cysA
Sulfate ABC transporter, ATPase subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
  
  
 0.843
Isop_1501
Sulfate ABC transporter, inner membrane subunit; COGs: COG4208 ABC-type sulfate transport system permease component; InterPro IPR000515: IPR005667; KEGG: cya:CYA_0468 sulfate ABC transporter, permease protein CysW; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Sulfate ABC transporter, permease protein CysW; TIGRFAM: sulfate ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: sulfate ABC transporter, permease protein CysW; sulfate ABC transporter, permease protein.
   
  
 0.834
Isop_1502
Sulfate ABC transporter, inner membrane subunit; COGs: COG0555 ABC-type sulfate transport system permease component; InterPro IPR000515: IPR005667; KEGG: hau:Haur_0258 sulfate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Sulfate ABC transporter, inner membrane subunit; TIGRFAM: sulfate ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: sulfate ABC transporter, permease protein CysW; sulfate ABC transporter, permease protein; sulfate ABC [...]
  
  
 0.801
Isop_2222
Ferredoxin; COGs: COG0633 Ferredoxin; InterPro IPR001055: IPR001041; KEGG: cyt:cce_2108 ferredoxin; PFAM: ferredoxin; SPTR: Probable ferredoxin; PFAM: 2Fe-2S iron-sulfur cluster binding domain.
   
 
 0.766
cysH
Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.746
Isop_3300
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR003043: IPR006366: IPR000878: IPR003754; KEGG: gme:Gmet_3235 uroporphyrinogen-III synthase/uroporphyrinogen-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
  
  
 0.741
rplY
Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
    
   0.717
Isop_1529
6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: hoh:Hoch_3369 6-phosphogluconate dehydrogenase NAD-binding protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 3-hydroxyisobutyrate dehydrogenase; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase.
       0.682
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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