STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_15296-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: hoh:Hoch_3369 6-phosphogluconate dehydrogenase NAD-binding protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 3-hydroxyisobutyrate dehydrogenase; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. (317 aa)    
Predicted Functional Partners:
Isop_1288
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160: IPR001261; KEGG: plm:Plim_1868 retinal dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Retinal dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
 
 0.916
Isop_1924
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR011278: IPR019810; KEGG: psl:Psta_3158 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 
 0.836
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.829
Isop_0416
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: sth:STH413 pyruvate dehydrogenase E2; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Pyruvate dehydrogenase E2; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
     
 0.809
Isop_1388
COGs: COG1882 Pyruvate-formate lyase; InterPro IPR001150: IPR005949: IPR004184: IPR019777; KEGG: cya:CYA_0477 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: formate acetyltransferase; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1.
     
  0.800
Isop_1624
Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
     
  0.800
Isop_1528
Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0369 Sulfite reductase alpha subunit (flavoprotein); InterProIPR017927: IPR001709: IPR012146: IPR008333: IPR 001433; KEGG: gvi:gvip312 ferredoxin--NADP+ reductase; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: Ferredoxin--NADP+ reductase; manually curated; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain.
       0.682
Isop_1527
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR011762: IPR011763: IPR000022; KEGG: psl:Psta_0088 propionyl-CoA carboxylase; PFAM: carboxyl transferase; PRIAM: Methylcrotonoyl-CoA carboxylase; SPTR: Propionyl-CoA carboxylase; PFAM: Carboxyl transferase domain.
 
    0.611
Isop_1530
COGs: COG0657 Esterase/lipase; KEGG: psl:Psta_2974 alpha/beta hydrolase fold-3 domain protein; SPTR: Alpha/beta hydrolase fold-3 domain protein; PFAM: alpha/beta hydrolase fold.
       0.581
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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