Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Isop_1550Hypothetical protein; COGs: COG1196 Chromosome segregation ATPase; KEGG: lma:LmjF34.0690 hypothetical protein; SPTR: Putative uncharacterized protein. (1474 aa)    
Predicted Functional Partners:
Isop_2792
MJ0042 family finger-like protein; InterPro IPR019825: IPR011723; KEGG: lma:LmjF34.0690 hypothetical protein; SPTR: Putative uncharacterized protein; TIGRFAM: MJ0042 family finger-like protein; TIGRFAM: MJ0042 family finger-like domain.
  
     0.737
Isop_3672
Hypothetical protein; InterPro IPR005819; KEGG: pcs:Pc22g03720 Pc22g03720; SPTR: Pc22g03720 protein.
  
 
   0.631
Isop_2664
KEGG: lma:LmjF34.0690 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.621
Isop_3293
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR018329: IPR014001: IPR001650: IPR014021: IPR 011545: IPR018982; KEGG: psl:Psta_2965 ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; RQC domain; SMART: DEAD-like helicase; helicase domain protein; SPTR: ATP-dependent DNA helicase, RecQ family; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; RQC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family.
  
 
 0.545
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.504
Isop_2395
Hypothetical protein; KEGG: rpc:RPC_3182 peptidase C14, caspase catalytic subunit P20; SPTR: Peptidase C14, caspase catalytic subunit p20.
  
     0.491
Isop_1650
COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR000565: IPR001241: IPR018522: IPR003594: IPR 013506: IPR002288; KEGG: psl:Psta_1044 DNA gyrase, B subunit; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; DNA gyrase subunit B domain protein; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: DNA gyrase subunit B; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus; TIGRFAM: DNA gyrase, B s [...]
   
 
 0.486
Isop_3275
DNA topoisomerase IV subunit B; COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR018522: IPR001241: IPR000565: IPR003594: IPR 013506: IPR006171: IPR002288; KEGG: scl:sce4452 DNA gyrase subunit B; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain-containing protein; DNA gyrase subunit B domain protein; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: DNA gyrase subunit B; PFAM: Histidine kinase-, [...]
   
 
 0.486
Isop_1549
KEGG: psl:Psta_1016 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.458
Isop_3366
KEGG: scl:sce1944 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 
 0.451
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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