STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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yacGProtein of unknown function DUF329; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (70 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.601
Isop_3274
COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR002205: IPR006691; KEGG: srm:SRM_01676 DNA gyrase subunit A; PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A; SPTR: DNA gyrase subunit A; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller.
    
 
 0.601
Isop_1650
COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR000565: IPR001241: IPR018522: IPR003594: IPR 013506: IPR002288; KEGG: psl:Psta_1044 DNA gyrase, B subunit; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; DNA gyrase subunit B domain protein; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: DNA gyrase subunit B; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus; TIGRFAM: DNA gyrase, B s [...]
    
 
 0.595
Isop_3275
DNA topoisomerase IV subunit B; COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR018522: IPR001241: IPR000565: IPR003594: IPR 013506: IPR006171: IPR002288; KEGG: scl:sce4452 DNA gyrase subunit B; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain-containing protein; DNA gyrase subunit B domain protein; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: DNA gyrase subunit B; PFAM: Histidine kinase-, [...]
    
 
 0.595
Isop_1570
Regulatory protein, FmdB family; COGs: COG2331 conserved hypothetical protein; InterPro IPR013429; KEGG: plm:Plim_2923 regulatory protein, FmdB family; PFAM: Putative regulatory protein FmdB; SPTR: Regulatory protein, FmdB family; TIGRFAM: regulatory protein, FmdB family; PFAM: Zinc ribbon domain; TIGRFAM: putative regulatory protein, FmdB family.
       0.545
Isop_1565
Hydroxyneurosporene synthase; InterPro IPR010791; KEGG: cch:Cag_0393 hydroxyneurosporene synthase CrtC; PFAM: hydroxyneurosporene synthase; SPTR: Hydroxyneurosporene synthase; PFAM: Hydroxyneurosporene synthase (CrtC).
       0.408
Isop_1566
COGs: COG1562 Phytoene/squalene synthetase; InterPro IPR019845: IPR002060; KEGG: mxa:MXAN_0896 phytoene synthetase; PFAM: Squalene/phytoene synthase; PRIAM: Phytoene synthase; SPTR: Phytoene synthase; PFAM: Squalene/phytoene synthase.
       0.408
Isop_1567
COGs: COG1233 Phytoene dehydrogenase and related protein; InterPro IPR008150: IPR014105: IPR002937; KEGG: hau:Haur_3185 zeta-phytoene desaturase; PFAM: amine oxidase; SPTR: Zeta-phytoene desaturase; TIGRFAM: phytoene desaturase; PFAM: Flavin containing amine oxidoreductase; TIGRFAM: phytoene desaturase.
       0.408
Isop_1568
Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: saq:Sare_4930 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: Polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
       0.408
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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