STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (422 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
Isop_0439
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR017900: IPR004489: IPR017896; KEGG: sro:Sros_8456 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; SPTR: Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
  
 0.975
Isop_0438
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR003953: IPR004112: IPR010916: IPR011280; KEGG: chl:Chy400_2032 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: Succinate dehydrogenase or fumarate reductase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit, Bacillus subtilis subgroup.
  
 0.974
Isop_0045
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.972
Isop_0044
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603: IPR001017: IPR005475; KEGG: sfu:Sfum_3547 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SPTR: 2-oxoglutarate dehydrogenase, E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
 
 0.955
Isop_0843
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: ace:Acel_0588 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases [...]
  
 0.937
Isop_1924
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR011278: IPR019810; KEGG: psl:Psta_3158 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 0.937
Isop_1582
COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006158: IPR006098: IPR006159: IPR006099; KEGG: mxa:MXAN_2263 methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-CoA mutase, alpha subunit; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase C-terminal domain.
  
 
 0.933
Isop_1583
COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006099; KEGG: rru:Rru_A2480 methylmalonyl-CoA mutase; PFAM: methylmalonyl-CoA mutase; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase, heterodimeric type, beta chain.
  
 
 0.933
Isop_0437
InterPro IPR011138; KEGG: amu:Amuc_0986 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; SPTR: Succinate dehydrogenase (Or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family.
    
 0.916
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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