STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1789SPFH domain, Band 7 family protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001972: IPR001107; KEGG: pca:Pcar_2837 membrane protease subunit, stomatin/prohibitin-like; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Putative uncharacterized protein; PFAM: SPFH domain / Band 7 family. (375 aa)    
Predicted Functional Partners:
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.711
Isop_0543
AAA ATPase central domain protein; COGs: COG0465 ATP-dependent Zn protease; InterPro IPR003959: IPR000642: IPR003593: IPR003960; KEGG: mxa:MXAN_2898 ATP-dependent metalloprotease FtsH; PFAM: AAA ATPase central domain protein; peptidase M41; SMART: AAA ATPase; SPTR: ATP-dependent metalloprotease, FtsH family; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.
   
 0.711
Isop_0868
Cytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
   
   0.591
Isop_3158
Cyclic nucleotide-binding protein; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR017900: IPR018528: IPR018488: IPR002373: IPR 000595: IPR001041: IPR017896; KEGG: sus:Acid_4310 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; ferredoxin; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain.
  
 
 0.586
Isop_1846
KEGG: psl:Psta_4608 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.546
Isop_1173
Protein of unknown function DUF179; COGs: COG1678 Putative transcriptional regulator protein; InterPro IPR003774; KEGG: psl:Psta_3870 protein of unknown function DUF179; PFAM: protein of unknown function DUF179; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1678; Belongs to the UPF0301 (AlgH) family.
   
    0.477
Isop_2610
Membrane protein insertase, YidC/Oxa1 family; COGs: COG0706 Preprotein translocase subunit YidC; InterPro IPR001708: IPR019998: IPR020001; KEGG: plm:Plim_1710 60 kDa inner membrane insertion protein; PFAM: 60 kDa inner membrane insertion protein; SPTR: Putative uncharacterized protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family; membrane protein insertase, YidC/Oxa1 family domain containing; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain; membrane protein insertase, YidC/Oxa1 family, N-terminal domain.
  
 
 0.402
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.