Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Isop_1820DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: psl:Psta_1070 DNA protecting protein DprA; PFAM: SMF family protein; SPTR: DNA processing chain A; TIGRFAM: DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. (453 aa)    
Predicted Functional Partners:
Isop_2397
COGs: COG0658 membrane metal-binding protein; InterPro IPR004477: IPR000073; KEGG: rba:RB9840 competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; alpha/beta hydrolase fold; SPTR: Probable competence protein; TIGRFAM: ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; X-Pro dipeptidyl-peptidase (S15 family); TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
 
  
 0.908
Isop_0196
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: cja:CJA_0425 competence protein ComF; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
 
 
 0.879
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
     
 0.796
Isop_0266
Mg chelatase, subunit ChlI; COGs: COG0606 ATPase with chaperone activity; InterPro IPR004482: IPR001208: IPR000523: IPR003593; KEGG: plm:Plim_0159 Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; SPTR: Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: Magnesium chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein.
 
 0.746
Isop_0643
Peptidase A24A prepilin type IV; InterPro IPR000045; KEGG: plm:Plim_1841 peptidase A24A domain protein; PFAM: peptidase A24A prepilin type IV; SPTR: Probable type 4 prepilin-like proteins leader peptide processing enzyme; PFAM: Type IV leader peptidase family.
  
  
 0.678
Isop_2952
Peptidase A24A domain protein; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627; KEGG: plm:Plim_1574 peptidase A24A domain protein; PFAM: peptidase A24A domain protein; SPTR: Peptidase A24A domain protein; PFAM: Bacterial Peptidase A24 N-terminal domain.
  
  
 0.678
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.661
Isop_2636
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR010822: IPR003594: IPR001932; KEGG: cli:Clim_1832 putative PAS/PAC sensor protein; PFAM: Stage II sporulation protein E; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Putative PAS/PAC sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Stage II sporulation protein E (SpoIIE).
   
    0.617
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.552
recR
DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
   
 0.532
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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