Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_1846KEGG: psl:Psta_4608 hypothetical protein; SPTR: Putative uncharacterized protein. (309 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.903
Isop_0191
KEGG: xcb:XC_0878 protein kinases, catalytic domain; region: PKc_like; cl09925; SPTR: Putative uncharacterized protein.
    
 0.869
Isop_2985
Ankyrin; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110: IPR020683; KEGG: sin:YN1551_2013 ankyrin; PFAM: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat.
  
 0.847
Isop_3434
Metallophosphoesterase; InterPro IPR004843; KEGG: psl:Psta_1609 hypothetical protein; PFAM: metallophosphoesterase; SPTR: Putative uncharacterized protein; PFAM: Calcineurin-like phosphoesterase.
   
 0.844
Isop_3158
Cyclic nucleotide-binding protein; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR017900: IPR018528: IPR018488: IPR002373: IPR 000595: IPR001041: IPR017896; KEGG: sus:Acid_4310 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; ferredoxin; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain.
    
 0.806
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
    
 0.762
Isop_0055
Cyclic nucleotide-binding protein; InterPro IPR000595; KEGG: tcr:504449.30 hypothetical protein; PFAM: cyclic nucleotide-binding; SPTR: Putative uncharacterized protein; PFAM: Cyclic nucleotide-binding domain.
    
 0.730
Isop_1026
KEGG: plm:Plim_2686 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 0.711
Isop_1339
KEGG: plm:Plim_0620 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 0.711
Isop_0219
ATP-binding region ATPase domain protein; COGs: COG0326 Molecular chaperone HSP90 family; InterPro IPR001404: IPR020575: IPR003594; KEGG: lic:LIC12469 HSP90 family protein; PFAM: ATP-binding region ATPase domain protein; SPTR: HtpG; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
   
 0.676
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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