STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Isop_1931Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000253: IPR000160; KEGG: scl:sce8626 FHA domain-containing protein; PFAM: GGDEF domain containing protein; Forkhead-associated protein; SMART: GGDEF domain containing protein; Forkhead-associated protein; SPTR: FHA domain protein; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain; FHA domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (367 aa)    
Predicted Functional Partners:
Isop_2462
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: plm:Plim_2180 response regulator receiver; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver; PFAM: Response regulator receiver domain.
 
  
 0.920
Isop_3677
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: ter:Tery_3248 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain.
 
 
  
 0.898
Isop_3271
COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358: IPR000014: IPR001610: IPR003661: IPR 003594: IPR001789: IPR005467: IPR000700: IPR008207: IPR013767; KEGG: psl:Psta_1412 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing protein; response regulator receiver; SPTR: PAS/PAC sensor hybrid h [...]
 
 
 0.839
Isop_1972
COGs: COG0642 Signal transduction histidine kinase; InterProIPR013655: IPR013767: IPR003661: IPR003594: IPR 001789: IPR008207: IPR000014: IPR004358: IPR000896: IPR005467; KEGG: rba:RB159 sensory transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; Hpt domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensory transduction histidine k [...]
 
 
 0.777
Isop_2636
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR010822: IPR003594: IPR001932; KEGG: cli:Clim_1832 putative PAS/PAC sensor protein; PFAM: Stage II sporulation protein E; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Putative PAS/PAC sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Stage II sporulation protein E (SpoIIE).
  
 
 0.756
Isop_0911
GAF sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003018: IPR003661: IPR003594: IPR001789: IPR 005467: IPR004358; KEGG: tcx:Tcr_2068 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; response regulator receiver; SPTR: Sensory transduction histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, D [...]
  
 0.743
Isop_1557
Response regulator receiver modulated metal dependent phosphohydrolase; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR001789: IPR003607: IPR006674; KEGG: dak:DaAHT2_0731 response regulator receiver modulated metal dependent phosphohydrolase; PFAM: response regulator receiver; metal-dependent phosphohydrolase HD sub domain; SMART: response regulator receiver; metal-dependent phosphohydrolase HD region; SPTR: Response regulator receiver modulated metal dependent phosphohydrolase; PFAM: HD domain; Response regulator receiver domain.
 
  
 0.722
Isop_1037
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014: IPR001610: IPR003661: IPR003594: IPR 001789: IPR005467: IPR013767: IPR013656: IPR004358; KEGG: cyb:CYB_1640 sensory box histidine kinase/response regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing protein; response regul [...]
 
 
 0.679
Isop_0220
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 004358: IPR013655: IPR003661: IPR003594: IPR001610; KEGG: dma:DMR_33580 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAC repeat-containing protein; PAS domain containing protein; response regulator receiver; SPTR: Two-compo [...]
 
 
 0.677
Isop_2980
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR004358: IPR 003661: IPR003594: IPR013767; KEGG: psl:Psta_1412 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; response regulator receiver; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein [...]
 
 
 0.676
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.