STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1955NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: neu:NE1170 putative dihydroflavonol-4-reductase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: hopanoid-associated sugar epimerase. (380 aa)    
Predicted Functional Partners:
Isop_2285
COGs: COG1657 Squalene cyclase; InterPro IPR006400: IPR018333: IPR001330; KEGG: psl:Psta_1738 squalene-hopene cyclase; PFAM: Prenyltransferase/squalene oxidase; PRIAM: Squalene--hopene cyclase; SPTR: Squalene-hopene cyclase; TIGRFAM: squalene-hopene cyclase; squalene/oxidosqualene cyclase; PFAM: Prenyltransferase and squalene oxidase repeat; TIGRFAM: squalene/oxidosqualene cyclases; squalene-hopene cyclase.
 
   0.796
Isop_1956
KEGG: plm:Plim_0336 hypothetical protein; SPTR: Dolichyl-phosphate-mannose-protein mannosyltransferase protein.
  
    0.781
Isop_2284
Hopanoid biosynthesis associated radical SAM protein HpnH; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR017833: IPR007197; KEGG: ppd:Ppro_1192 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: Molybdenum cofactor biosynthesis protein A; TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM superfamily; Domain of unknown function (DUF3463); TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH.
 
     0.730
rpsS
SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
   
  0.637
rpsZ
SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
   
  0.636
rpsL
SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
   
 0.632
rpsQ
SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
  0.628
rpsC
SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
   
  0.623
rpsE
SSU ribosomal protein S5P; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.
   
  0.620
rpsH
SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.
   
  0.614
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.