STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Isop_2004COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014030: IPR014031: IPR013114; KEGG: glo:Glov_2268 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase; Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; SPTR: Beta-ketoacyl synthase; PFAM: FabA-like domain; Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: PfaB family protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (2373 aa)    
Predicted Functional Partners:
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
 
 
0.986
Isop_2005
COGs: COG0332 3-oxoacyl-(acyl-carrier-protein); InterPro IPR013747; KEGG: plm:Plim_3323 3-oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain-containing protein; SPTR: 3-Oxoacyl-(Acyl-carrier-protein (ACP)) synthase III domain protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Thiolase, N-terminal domain.
 
  
 0.973
Isop_2001
PfaD family protein; COGs: COG2070 Dioxygenase related to 2-nitropropane dioxygenase; InterPro IPR004136: IPR014179; KEGG: plm:Plim_0463 PfaD family protein; PFAM: 2-nitropropane dioxygenase NPD; SPTR: PfaD family protein; TIGRFAM: PfaD family protein; PFAM: 2-nitropropane dioxygenase; TIGRFAM: PfaD family protein.
  
 0.935
Isop_0450
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043: IPR004410; KEGG: psl:Psta_1725 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase.
 
 0.896
Isop_1875
COGs: COG2091 Phosphopantetheinyl transferase; InterPro IPR008278; KEGG: ava:Ava_2597 4'-phosphopantetheinyl transferase; PFAM: 4'-phosphopantetheinyl transferase; SPTR: 4'-phosphopantetheinyl transferase; PFAM: 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily.
 
 0.876
Isop_2006
COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073: IPR000639; KEGG: glo:Glov_2270 alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold; SPTR: Alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold.
 
  
 0.856
Isop_2002
COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014030: IPR018201; KEGG: gur:Gura_2012 erythronolide synthase; PFAM: Beta-ketoacyl synthase; SPTR: Erythronolide synthase; PFAM: Beta-ketoacyl synthase, N-terminal domain.
 
  
0.850
Isop_1050
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873: IPR020845; KEGG: geo:Geob_3151 peptide synthase; PFAM: AMP-dependent synthetase and ligase; SPTR: AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme.
 
 0.816
fabH
3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
  
  
 0.780
Isop_3634
Thioesterase superfamily protein; COGs: COG0824 thioesterase; InterPro IPR006684: IPR006683; KEGG: plm:Plim_2936 thioesterase superfamily protein; PFAM: thioesterase superfamily protein; SPTR: Putative uncharacterized protein; PFAM: Thioesterase superfamily; TIGRFAM: acyl-CoA thioester hydrolase, YbgC/YbaW family.
  
 
 0.720
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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