STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2006COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073: IPR000639; KEGG: glo:Glov_2270 alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold; SPTR: Alpha/beta hydrolase fold; PFAM: alpha/beta hydrolase fold. (321 aa)    
Predicted Functional Partners:
Isop_1050
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873: IPR020845; KEGG: geo:Geob_3151 peptide synthase; PFAM: AMP-dependent synthetase and ligase; SPTR: AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme.
 
 
 0.979
Isop_2005
COGs: COG0332 3-oxoacyl-(acyl-carrier-protein); InterPro IPR013747; KEGG: plm:Plim_3323 3-oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain-containing protein; SPTR: 3-Oxoacyl-(Acyl-carrier-protein (ACP)) synthase III domain protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Thiolase, N-terminal domain.
 
  
 0.950
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
 
 
 0.947
Isop_2004
COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014030: IPR014031: IPR013114; KEGG: glo:Glov_2268 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase; Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; SPTR: Beta-ketoacyl synthase; PFAM: FabA-like domain; Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: PfaB family protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
  
 0.856
Isop_2002
COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014030: IPR018201; KEGG: gur:Gura_2012 erythronolide synthase; PFAM: Beta-ketoacyl synthase; SPTR: Erythronolide synthase; PFAM: Beta-ketoacyl synthase, N-terminal domain.
 
  
 0.812
Isop_1049
3-beta hydroxysteroid dehydrogenase/isomerase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; KEGG: geo:Geob_3152 3-beta hydroxysteroid dehydrogenase/isomerase; SPTR: 3-beta hydroxysteroid dehydrogenase/isomerase; PFAM: 3-beta hydroxysteroid dehydrogenase/isomerase family.
 
     0.778
Isop_2001
PfaD family protein; COGs: COG2070 Dioxygenase related to 2-nitropropane dioxygenase; InterPro IPR004136: IPR014179; KEGG: plm:Plim_0463 PfaD family protein; PFAM: 2-nitropropane dioxygenase NPD; SPTR: PfaD family protein; TIGRFAM: PfaD family protein; PFAM: 2-nitropropane dioxygenase; TIGRFAM: PfaD family protein.
 
    0.711
Isop_3434
Metallophosphoesterase; InterPro IPR004843; KEGG: psl:Psta_1609 hypothetical protein; PFAM: metallophosphoesterase; SPTR: Putative uncharacterized protein; PFAM: Calcineurin-like phosphoesterase.
    
  0.666
Isop_2613
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: plm:Plim_0206 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: Probable oxidoreductase; PFAM: NAD dependent epimerase/dehydratase family.
  
     0.532
Isop_3340
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: rba:RB10858 oxidoreductase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family.
  
     0.530
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.