Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2054Protein of unknown function DUF37; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (92 aa)    
Predicted Functional Partners:
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.968
Isop_2610
Membrane protein insertase, YidC/Oxa1 family; COGs: COG0706 Preprotein translocase subunit YidC; InterPro IPR001708: IPR019998: IPR020001; KEGG: plm:Plim_1710 60 kDa inner membrane insertion protein; PFAM: 60 kDa inner membrane insertion protein; SPTR: Putative uncharacterized protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family; membrane protein insertase, YidC/Oxa1 family domain containing; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain; membrane protein insertase, YidC/Oxa1 family, N-terminal domain.
  
  
 0.752
secE
Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family.
   
    0.727
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
  
    0.665
Isop_1268
Methyltransferase; COGs: COG0742 N6-adenine-specific methylase; InterPro IPR004398: IPR002052; KEGG: sfu:Sfum_3033 putative methyltransferase; PFAM: Conserved hypothetical protein CHP00095; SPTR: Putative methyltransferase; TIGRFAM: methyltransferase; manually curated; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family.
  
    0.662
Isop_2052
Hypothetical protein; KEGG: gla:GL50803_113836 High cysteine membrane protein EGF-like; SPTR: High cysteine membrane protein EGF-like.
       0.626
Isop_0332
tRNA synthetase class II (G H P and S); InterPro IPR002314: IPR000408: IPR006195; KEGG: scl:sce6565 hypothetical protein; PFAM: tRNA synthetase class II (G H P and S); SPTR: SerS1 protein; PFAM: tRNA synthetase class II core domain (G, H, P, S and T).
  
    0.620
Isop_0333
Hypothetical protein; InterPro IPR000182; KEGG: scl:sce6566 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.620
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
  
    0.620
rplB
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
    0.617
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.