STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2070Alcohol dehydrogenase GroES domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR013154: IPR013149; KEGG: plm:Plim_0729 alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: Alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (327 aa)    
Predicted Functional Partners:
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
  
 
 0.747
Isop_0191
KEGG: xcb:XC_0878 protein kinases, catalytic domain; region: PKc_like; cl09925; SPTR: Putative uncharacterized protein.
    
 
 0.558
Isop_3004
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932: IPR014045: IPR010822; KEGG: psl:Psta_1567 protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C-like; Stage II sporulation protein E; SMART: protein phosphatase 2C domain protein; SPTR: Protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C.
    
   0.468
Isop_3386
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR014045: IPR001932; KEGG: plm:Plim_2397 phosphoprotein phosphatase; PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; SPTR: Protein phosphatase; PFAM: Protein phosphatase 2C.
    
   0.468
Isop_0425
AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterProIPR003338: IPR004201: IPR003959: IPR003593: IPR 003960: IPR005938; KEGG: mxa:MXAN_2773 AAA family ATPase; PFAM: AAA ATPase central domain protein; AAA ATPase VAT domain protein; cell division protein 48 CDC48 domain 2; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: ATPase, AAA family; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), N-terminal domain; Cell division protein 48 (CDC48), domain 2; [...]
    
   0.465
Isop_2152
Alcohol dehydrogenase zinc-binding domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR018130: IPR013154: IPR013149; KEGG: gbe:GbCGDNIH1_0098 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: Alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.
  
     0.459
Isop_1293
COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130: IPR011506: IPR001343; KEGG: psl:Psta_1955 peptidyl-prolyl cis-trans isomerase cyclophilin type; PFAM: peptidyl-prolyl cis-trans isomerase cyclophilin type; Planctomycete extracellular domain protein; Hemolysin-type calcium-binding region; SPTR: Peptidyl-prolyl cis-trans isomerase cyclophilin type; PFAM: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD.
    
   0.444
Isop_1521
Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
    
   0.444
Isop_2071
DNA methylase N-4/N-6 domain protein; COGs: COG0863 DNA modification methylase; InterPro IPR002941: IPR001091: IPR002052; KEGG: chl:Chy400_0713 DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase N-4/N-6 domain protein; SPTR: DNA methylase; PFAM: DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family.
       0.433
Isop_2908
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: cag:Cagg_1601 histone deacetylase superfamily; PFAM: histone deacetylase superfamily; PRIAM: Histone deacetylase; SPTR: Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
   
   0.430
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.