STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Isop_2071DNA methylase N-4/N-6 domain protein; COGs: COG0863 DNA modification methylase; InterPro IPR002941: IPR001091: IPR002052; KEGG: chl:Chy400_0713 DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase N-4/N-6 domain protein; SPTR: DNA methylase; PFAM: DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. (327 aa)    
Predicted Functional Partners:
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
    
 0.802
Isop_3377
DNA methylase N-4/N-6 domain protein; COGs: COG2189 Adenine specific DNA methylase Mod; InterPro IPR002941: IPR002295: IPR002052: IPR016059; KEGG: aeh:Mlg_1539 DNA methylase N-4/N-6 domain-containing protein; PFAM: DNA methylase N-4/N-6 domain protein; SPTR: DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase.
 
   
 0.479
Isop_3557
D12 class N6 adenine-specific DNA methyltransferase; COGs: COG0338 Site-specific DNA methylase; InterPro IPR012327: IPR002294; KEGG: rrs:RoseRS_0743 D12 class N6 adenine-specific DNA methyltransferase; PFAM: D12 class N6 adenine-specific DNA methyltransferase; SPTR: D12 class N6 adenine-specific DNA methyltransferase; PFAM: D12 class N6 adenine-specific DNA methyltransferase.
 
  
 0.448
Isop_2070
Alcohol dehydrogenase GroES domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR013154: IPR013149; KEGG: plm:Plim_0729 alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: Alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.
       0.433
Isop_2445
ParB domain protein nuclease; COGs: COG0863 DNA modification methylase; InterPro IPR003115: IPR002941: IPR002295: IPR015840; KEGG: cbe:Cbei_1632 DNA methylase N-4/N-6 domain-containing protein; PFAM: ParB domain protein nuclease; DNA methylase N-4/N-6 domain protein; SMART: ParB domain protein nuclease; SPTR: DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase; ParB-like nuclease domain.
  
     0.420
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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