STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2227COGs: COG5002 Signal transduction histidine kinase; InterProIPR000014: IPR003661: IPR003594: IPR004358: IPR 013767: IPR005467; KEGG: plm:Plim_1491 PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensory box sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domai [...] (460 aa)    
Predicted Functional Partners:
Isop_0022
Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: psl:Psta_2596 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Phosphate regulon response regulator PhoB; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
 0.987
Isop_2462
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: plm:Plim_2180 response regulator receiver; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver; PFAM: Response regulator receiver domain.
 
 0.936
Isop_1842
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: afw:Anae109_0804 multi-sensor signal transduction histidine kinase; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain.
 
 
 0.883
Isop_3677
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: ter:Tery_3248 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain.
 
 0.866
Isop_1972
COGs: COG0642 Signal transduction histidine kinase; InterProIPR013655: IPR013767: IPR003661: IPR003594: IPR 001789: IPR008207: IPR000014: IPR004358: IPR000896: IPR005467; KEGG: rba:RB159 sensory transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; Hpt domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensory transduction histidine k [...]
 
 
0.834
Isop_2635
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: adg:Adeg_1011 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain.
 
 
 0.819
Isop_1453
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: psl:Psta_3399 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain.
 
 
 0.818
Isop_3686
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: lch:Lcho_3971 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain.
 
   
 0.786
Isop_2228
Hypothetical protein; COGs: COG0663 Carbonic anhydrase/acetyltransferase isoleucine patch superfamily; InterPro IPR001451; KEGG: mxa:MXAN_3783 hexapaptide repeat-containing transferase; SPTR: Transferase hexapeptide repeat family protein.
       0.782
Isop_3511
Response regulator receiver and Hpt phospho transfer protein; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789: IPR008207; KEGG: mgm:Mmc1_3271 PAS/PAC sensor hybrid histidine kinase; PFAM: response regulator receiver; Hpt domain protein; SMART: response regulator receiver; SPTR: Putative uncharacterized protein; PFAM: Response regulator receiver domain; Hpt domain.
 
 
 
 0.780
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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