STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2230KEGG: cpi:Cpin_1878 hypothetical protein; SPTR: Putative uncharacterized protein. (191 aa)    
Predicted Functional Partners:
Isop_2145
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.855
Isop_2231
COGs: COG0308 Aminopeptidase N; KEGG: rba:RB5627 aminopeptidase; SPTR: Putative aminopeptidase; PFAM: Peptidase family M1.
 
     0.705
Isop_2877
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
   
 
 0.620
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 
 0.519
Isop_2769
Membrane-bound dehydrogenase domain protein; InterPro IPR009056: IPR003088: IPR013428: IPR013427; KEGG: dfe:Dfer_5354 membrane-bound dehydrogenase domain protein; PFAM: cytochrome c class I; SPTR: Putative uncharacterized protein; TIGRFAM: membrane-bound dehydrogenase domain protein; heme-binding protein; PFAM: Cytochrome c; TIGRFAM: putative membrane-bound dehydrogenase domain; putative heme-binding domain, Pirellula/Verrucomicrobium type.
  
     0.516
Isop_2380
Membrane-bound dehydrogenase domain protein; COGs: COG3828 conserved hypothetical protein; InterPro IPR013428: IPR013427: IPR009056; KEGG: psl:Psta_1431 membrane-bound dehydrogenase domain protein; SPTR: Membrane-bound dehydrogenase domain protein; TIGRFAM: membrane-bound dehydrogenase domain protein; heme-binding protein; PFAM: Cytochrome c; Trehalose utilisation; Membrane bound L-sorbosone dehydrogenase; TIGRFAM: putative membrane-bound dehydrogenase domain; putative heme-binding domain, Pirellula/Verrucomicrobium type.
  
     0.509
Isop_3240
InterPro IPR000089; KEGG: mfa:Mfla_2222 secretion protein HlyD; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Secretion protein HlyD.
  
     0.504
Isop_0147
Membrane-bound dehydrogenase domain protein; COGs: COG2133 Glucose/sorbosone dehydrogenase; InterPro IPR009056: IPR013428: IPR013427; KEGG: sli:Slin_5811 membrane-bound dehydrogenase domain protein; SPTR: Membrane-bound dehydrogenase domain protein; TIGRFAM: membrane-bound dehydrogenase domain protein; heme-binding protein; PFAM: Cytochrome c; HEAT repeat; TIGRFAM: putative membrane-bound dehydrogenase domain; putative heme-binding domain, Pirellula/Verrucomicrobium type.
  
     0.432
Isop_0828
Sugar isomerase (SIS); COGs: COG0279 Phosphoheptose isomerase; InterPro IPR001347; KEGG: plm:Plim_1528 sugar isomerase (SIS); PFAM: sugar isomerase (SIS); SPTR: Sugar isomerase (SIS); PFAM: SIS domain.
    
 
 0.406
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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