STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2283COGs: COG0775 Nucleoside phosphorylase; InterPro IPR000845; KEGG: psl:Psta_1736 purine or other phosphorylase family 1; PFAM: purine or other phosphorylase family 1; SPTR: Purine or other phosphorylase family 1; PFAM: Phosphorylase superfamily. (267 aa)    
Predicted Functional Partners:
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
 0.919
Isop_2284
Hopanoid biosynthesis associated radical SAM protein HpnH; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR017833: IPR007197; KEGG: ppd:Ppro_1192 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: Molybdenum cofactor biosynthesis protein A; TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM superfamily; Domain of unknown function (DUF3463); TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH.
 
   
 0.688
Isop_2285
COGs: COG1657 Squalene cyclase; InterPro IPR006400: IPR018333: IPR001330; KEGG: psl:Psta_1738 squalene-hopene cyclase; PFAM: Prenyltransferase/squalene oxidase; PRIAM: Squalene--hopene cyclase; SPTR: Squalene-hopene cyclase; TIGRFAM: squalene-hopene cyclase; squalene/oxidosqualene cyclase; PFAM: Prenyltransferase and squalene oxidase repeat; TIGRFAM: squalene/oxidosqualene cyclases; squalene-hopene cyclase.
 
   
 0.580
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.542
Isop_2214
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.523
Isop_3535
Von Willebrand factor type A; COGs: COG4867 Uncharacterized protein with a von Willebrand factor type A (vWA) domain; InterPro IPR002035; KEGG: plm:Plim_0521 von Willebrand factor type A; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A; SPTR: von Willebrand factor type A; PFAM: von Willebrand factor type A domain.
  
 
   0.497
Isop_0668
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.490
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.487
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.469
Isop_1800
KEGG: psl:Psta_3976 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.464
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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