Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_2442Endodeoxyribonuclease RusA; COGs: COG4570 Holliday junction resolvase; InterPro IPR008822; KEGG: sgl:SG0745 putative phage endonuclease; PFAM: endodeoxyribonuclease RusA; SPTR: Endodeoxyribonuclease RusA; PFAM: Endodeoxyribonuclease RusA. (149 aa)    
Predicted Functional Partners:
Isop_2443
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterProIPR014021: IPR001650: IPR006935: IPR018886: IPR 014001; KEGG: mag:amb0356 superfamily II DNA/RNA helicase; PFAM: type III restriction protein res subunit; helicase domain protein; Uncharacterised protein family UPF0547; SMART: helicase domain protein; DEAD-like helicase; SPTR: Helicase domain protein; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; Uncharacterised protein family UPF0547.
 
     0.856
Isop_2444
Bifunctional DNA primase/polymerase; COGs: COG3598 RecA-family ATPase; InterPro IPR015330: IPR014820; KEGG: aeh:Mlg_0791 ATPase-like protein; PFAM: Bifunctional DNA primase/polymerase; Primase 1; SPTR: Bifunctional DNA primase/polymerase; PFAM: Bifunctional DNA primase/polymerase, N-terminal; Primase C terminal 1 (PriCT-1).
 
     0.833
Isop_2439
KEGG: oan:Oant_0214 hypothetical protein; SPTR: Putative uncharacterized protein.
 
    0.795
Isop_2440
KEGG: mag:amb0352 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.631
Isop_2445
ParB domain protein nuclease; COGs: COG0863 DNA modification methylase; InterPro IPR003115: IPR002941: IPR002295: IPR015840; KEGG: cbe:Cbei_1632 DNA methylase N-4/N-6 domain-containing protein; PFAM: ParB domain protein nuclease; DNA methylase N-4/N-6 domain protein; SMART: ParB domain protein nuclease; SPTR: DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase; ParB-like nuclease domain.
 
     0.518
Isop_2435
Phage portal protein, lambda family; COGs: COG5511 Bacteriophage capsid protein; InterPro IPR006429; KEGG: lhk:LHK_01658 phage portal protein, lambda family; PFAM: portal protein lambda; SPTR: Phage portal protein, lambda family; TIGRFAM: phage portal protein, lambda family; PFAM: Phage portal protein, lambda family; TIGRFAM: phage portal protein, lambda family.
 
     0.516
Isop_2441
Protein of unknown function DUF669; InterPro IPR007731; KEGG: mgm:Mmc1_2920 hypothetical protein; PFAM: protein of unknown function DUF669; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF669).
       0.516
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
     0.513
Isop_2425
KEGG: sit:TM1040_1281 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.470
Isop_2452
KEGG: plm:Plim_2131 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Phage terminase large subunit (GpA).
 
     0.433
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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