STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.953
Isop_1413
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
  
 0.933
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.924
Isop_2784
COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638: IPR004393; KEGG: cag:Cagg_1774 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Quinolinate phosphoribosyl transferase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
    
 0.922
Isop_1139
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: scl:sce7444 NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; SPTR: Transcriptional regulatory protein, Sir2 family; manually curated; PFAM: Sir2 family.
   
 0.916
Isop_1122
Alanine dehydrogenase/PNT domain protein; COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; InterPro IPR007886: IPR007698; KEGG: sus:Acid_3375 NAD(P) transhydrogenase subunit alpha; PFAM: alanine dehydrogenase/PNT domain protein; SPTR: Alanine dehydrogenase/PNT domain protein; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: NAD(P) transhydrogenase, alpha subunit.
     
 0.903
Isop_1123
Hypothetical protein; COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; KEGG: hoh:Hoch_1909 oxidoreductase; SPTR: Proton-translocating transhydrogenase subunit alpha 2.
     
 0.903
Isop_1124
NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.903
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
Isop_3030
Stationary-phase survival protein SurE; COGs: COG0496 acid phosphatase; InterPro IPR002828; KEGG: cyt:cce_2598 stationary phase survival protein SurE; PFAM: Survival protein SurE; SPTR: Stationary-phase survival protein; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE.
     
  0.900
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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