STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2697methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (198 aa)    
Predicted Functional Partners:
Isop_0740
HhH-GPD family protein; COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR003265; KEGG: msv:Mesil_1125 HhH-GPD family protein; PFAM: HhH-GPD family protein; SMART: HhH-GPD family protein; SPTR: Probable DNA-3-methyladenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein.
 
  
 0.886
Isop_2145
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.576
Isop_3310
Domain of unknown function DUF1730; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR017900: IPR017896: IPR013542; KEGG: psl:Psta_2479 domain of unknown function DUF1730; PFAM: domain of unknown function DUF1730; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative.
      0.574
Isop_3496
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
      0.565
Isop_1251
UspA domain-containing protein; COGs: COG0531 Amino acid transporter; InterPro IPR006016; KEGG: pcu:pc0262 hypothetical protein; PFAM: UspA domain-containing protein; SPTR: Amino acid permease-associated region; PFAM: Universal stress protein family.
  
  
 0.551
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
   
 
 0.520
Isop_2672
COGs: COG0589 Universal stress protein UspA and related nucleotide-binding protein; InterPro IPR006016: IPR006015; KEGG: plm:Plim_2355 UspA domain protein; PFAM: UspA domain-containing protein; SPTR: UspA domain protein; PFAM: Universal stress protein family.
  
  
 0.512
Isop_1928
Excinuclease ABC C subunit domain protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
   
 0.482
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.