Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_2766COGs: COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain; InterPro IPR006650; KEGG: rca:Rcas_2756 hypothetical protein; SPTR: Uncharacterized protein containing SIS (Sugar isomerase) phosphosugar binding domain-like protein. (270 aa)    
Predicted Functional Partners:
Isop_2765
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR020904: IPR002198; KEGG: sli:Slin_5818 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
 
     0.880
Isop_2764
Endoribonuclease L-PSP; COGs: COG0251 Putative translation initiation inhibitor yjgF family; InterPro IPR006175; KEGG: rba:RB1270 putative translation initiation inhibitor; PFAM: Endoribonuclease L-PSP; SPTR: Endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP.
       0.780
Isop_0351
COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: rca:Rcas_2758 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; PFAM: Cobalamin-independent synthase, Catalytic domain.
 
     0.599
Isop_2981
Xylose isomerase domain-containing protein TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307: IPR011418; KEGG: rba:RB5053 hypothetical protein; PFAM: Xylose isomerase domain-containing protein TIM barrel; AP endonuclease 2 domain protein; SPTR: Putative uncharacterized protein; PFAM: AP endonuclease family 2 C terminus; Xylose isomerase-like TIM barrel.
  
     0.583
pdxJ
Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
       0.566
Isop_1380
KEGG: rca:Rcas_3850 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Neutral/alkaline non-lysosomal ceramidase.
 
     0.524
Isop_0352
Hypothetical protein; COGs: COG2220 Zn-dependent hydrolase of the beta-lactamase fold; KEGG: sli:Slin_6275 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.522
Isop_2763
Hypothetical protein; KEGG: sus:Acid_1421 glycosyl transferase family protein; SPTR: Tetratricopeptide repeat protein.
       0.477
Isop_2762
Hypothetical protein; KEGG: gym:GYMC10_4089 ABC transporter related protein; SPTR: Putative uncharacterized protein M88B7.1f.
       0.458
Isop_2519
KEGG: rbi:RB2501_02765 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Trehalose utilisation.
  
     0.431
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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