Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_2802Beta-lactamase domain protein; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; KEGG: psl:Psta_3932 beta-lactamase domain protein; SPTR: Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (260 aa)    
Predicted Functional Partners:
Isop_3580
Hypothetical protein; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; KEGG: dae:Dtox_2285 beta-lactamase domain protein; SPTR: Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily.
  
  
  0.940
Isop_2965
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140: IPR006139; KEGG: maq:Maqu_3853 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain.
   
 
  0.903
Isop_2019
InterPro IPR004360; KEGG: cvi:CV_2020 hypothetical protein; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Putative uncharacterized protein; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.
     
  0.900
Isop_3476
Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: sno:Snov_3500 protein of unknown function DUF2088; PFAM: Protein of unknown function DUF2088; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088).
     
  0.900
Isop_2700
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR001763: IPR013027: IPR004099; KEGG: psl:Psta_1619 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Rhodanese-like domain; Pyridine nucleotide-disul [...]
  
 0.687
Isop_0287
Amidohydrolase 2; COGs: COG1904 Glucuronate isomerase; KEGG: plm:Plim_2160 amidohydrolase 2; SPTR: Putative uncharacterized protein; PFAM: Glucuronate isomerase.
  
     0.630
Isop_2134
KEGG: cma:Cmaq_1622 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.539
Isop_3110
KEGG: plm:Plim_0161 protein of unknown function DUF1559; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1559).
  
     0.530
Isop_0204
KEGG: mac:MA3428 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.507
Isop_0681
Glycoside hydrolase family 10; COGs: COG3693 Beta-1 4-xylanase; KEGG: plm:Plim_3847 glycoside hydrolase family 10; SPTR: Glycoside hydrolase family 10.
  
     0.504
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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