STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Isop_28112-methylcitrate dehydratase; COGs: COG2079 Uncharacterized protein involved in propionate catabolism; InterPro IPR005656; KEGG: nde:NIDE3125 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein; PRIAM: 2-methylcitrate dehydratase; SPTR: 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family. (465 aa)    
Predicted Functional Partners:
Isop_1924
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR011278: IPR019810; KEGG: psl:Psta_3158 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
 
 0.991
prpB
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
  
 0.945
Isop_0840
Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.928
Isop_1527
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR011762: IPR011763: IPR000022; KEGG: psl:Psta_0088 propionyl-CoA carboxylase; PFAM: carboxyl transferase; PRIAM: Methylcrotonoyl-CoA carboxylase; SPTR: Propionyl-CoA carboxylase; PFAM: Carboxyl transferase domain.
  
    0.522
Isop_1588
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR011762: IPR011763: IPR000438: IPR000022; KEGG: sus:Acid_6960 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Carboxyl transferase; PFAM: Carboxyl transferase domain.
  
    0.522
Isop_2812
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR017909: IPR000683: IPR006311; KEGG: psl:Psta_2822 oxidoreductase domain protein; PFAM: oxidoreductase domain protein; SPTR: Oxidoreductase family, NAD-binding Rossmann fold protein; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
       0.496
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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