STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
Isop_2842NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: rrs:RoseRS_0359 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family. (331 aa)    
Predicted Functional Partners:
Isop_3609
COGs: COG1087 UDP-glucose 4-epimerase; InterPro IPR005886: IPR001509: IPR020904; KEGG: jan:Jann_4249 UDP-galactose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: UDP-galactose 4-epimerase; TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: UDP-glucose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
 
 
0.918
Isop_0060
Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR017476: IPR001732: IPR014026: IPR014027; KEGG: psl:Psta_1357 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: Nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose deh [...]
  
 0.917
Isop_0087
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: mmi:MMAR_2310 UDP-glucose 4-epimerase, GalE5; PFAM: NAD-dependent epimerase/dehydratase; SPTR: UDP-glucose 4-epimerase, GalE5; manually curated; PFAM: NAD dependent epimerase/dehydratase family.
  
  
 
0.911
Isop_1551
COGs: COG1085 Galactose-1-phosphate uridylyltransferase; InterPro IPR001937; KEGG: nde:NIDE3393 galactose-1-phosphate uridylyltransferase; PRIAM: UDP-glucose--hexose-1-phosphate uridylyltransferase; SPTR: Galactose-1-phosphate uridylyltransferase; PFAM: Galactose-1-phosphate uridyl transferase, N-terminal domain; TIGRFAM: galactose-1-phosphate uridylyltransferase, family 1.
   
 
 0.901
Isop_1451
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
 0.822
Isop_0381
COGs: COG0836 Mannose-1-phosphate guanylyltransferase; InterPro IPR005835: IPR001538; KEGG: ttr:Tter_0486 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II; PRIAM: Mannose-1-phosphate guanylyltransferase; SPTR: Mannose-1-phosphate guanylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase.
  
 
 0.808
Isop_0382
UTP--glucose-1-phosphate uridylyltransferase; COGs: COG4284 UDP-glucose pyrophosphorylase; InterPro IPR002618; KEGG: rba:RB6977 UDP-N-acetylhexosamine pyrophosphorylase; PFAM: UTP--glucose-1-phosphate uridylyltransferase; SPTR: UTP--glucose-1-phosphate uridylyltransferase subfamily; PFAM: UTP--glucose-1-phosphate uridylyltransferase.
     
  0.800
glmU
UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
     
 0.800
Isop_3611
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: afr:AFE_3291 NAD-dependent epimerase/dehydratase family protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase family protein; PFAM: NAD dependent epimerase/dehydratase family.
  
     0.685
Isop_0824
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR005835; KEGG: rrs:RoseRS_4077 nucleotidyl transferase; PFAM: Nucleotidyl transferase; SPTR: Nucleotidyl transferase; PFAM: Nucleotidyl transferase.
 
 
 0.588
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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