STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
Isop_2844Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR018300: IPR001544; KEGG: rxy:Rxyl_0760 aminotransferase, class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase, class IV; PFAM: Aminotransferase class IV. (313 aa)    
Predicted Functional Partners:
Isop_2650
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR006805: IPR015890: IPR019999: IPR005802; KEGG: mta:Moth_2108 aminodeoxychorismate synthase, subunit I; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: Aminodeoxychorismate synthase, subunit I; TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade.
 
 
 0.931
Isop_3561
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 
 0.927
Isop_2845
KEGG: psl:Psta_1684 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
Isop_1176
Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: ppp:PHYPADRAFT_141539 hypothetical protein; PFAM: aminotransferase class IV; SPTR: Putative branched chain amino acid aminotransferase; PFAM: Aminotransferase class IV.
  
     0.760
Isop_2843
Protein of unknown function DUF34; COGs: COG0327 conserved hypothetical protein; InterPro IPR002678: IPR017221; KEGG: plm:Plim_2674 protein of unknown function DUF34; PFAM: protein of unknown function DUF34; SPTR: Putative uncharacterized protein; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
  
    0.667
Isop_2846
COGs: COG2309 Leucyl aminopeptidase (aminopeptidase T); InterPro IPR000787: IPR018313; KEGG: cwo:Cwoe_1076 peptidase M29 aminopeptidase II; PFAM: peptidase M29 aminopeptidase II; SPTR: Peptidase M29 aminopeptidase II; PFAM: Thermophilic metalloprotease (M29).
       0.623
Isop_0095
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR005675: IPR002034: IPR013709; KEGG: plm:Plim_2070 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; SPTR: 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase [...]
  
 
 0.569
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.569
ilvD
COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR020558: IPR004404: IPR000581; KEGG: rxy:Rxyl_1326 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.539
Isop_3339
Dehydratase, YjhG/YagF family; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR017798: IPR000581: IPR020558; KEGG: psl:Psta_2493 dehydratase, YjhG/YagF family; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dehydratase, YjhG/YagF family; TIGRFAM: dehydratase, YjhG/YagF family; PFAM: Dehydratase family; TIGRFAM: probable dehydratase, YjhG/YagF family; Belongs to the IlvD/Edd family.
  
 
 0.539
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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