STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Isop_2855Putative DNA glycosylase; COGs: COG0177 EndoIII-related endonuclease; KEGG: dma:DMR_17660 putative DNA glycosylase; SPTR: HhH-GPD protein. (243 aa)    
Predicted Functional Partners:
Isop_2880
Endonuclease/exonuclease/phosphatase; InterPro IPR019775: IPR005135; KEGG: ank:AnaeK_2753 endonuclease/exonuclease/phosphatase; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Endonuclease/exonuclease/phosphatase; PFAM: Endonuclease/Exonuclease/phosphatase family.
  
 0.729
nfo
Apurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.626
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
   
 
 0.609
Isop_2198
COGs: COG3379 conserved hypothetical protein; InterPro IPR005829: IPR002591; KEGG: htu:Htur_5256 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: Type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase.
  
     0.496
Isop_3037
Protein of unknown function DUF164; COGs: COG1579 Zn-ribbon protein possibly nucleic acid-binding; InterPro IPR003743; KEGG: plm:Plim_0030 protein of unknown function DUF164; PFAM: protein of unknown function DUF164; SPTR: Putative uncharacterized protein; PFAM: Putative zinc ribbon domain.
 
     0.496
Isop_1473
Protein of unknown function DUF62; COGs: COG1912 conserved hypothetical protein; InterPro IPR002747; KEGG: psl:Psta_4032 protein of unknown function DUF62; PFAM: protein of unknown function DUF62; SPTR: Putative uncharacterized protein; PFAM: S-adenosyl-l-methionine hydroxide adenosyltransferase.
  
     0.476
Isop_2007
COGs: COG3379 conserved hypothetical protein; InterPro IPR002591; KEGG: hor:Hore_17270 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: Type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase.
  
     0.442
Isop_0585
COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR019304: IPR006124: IPR004456: IPR013371; KEGG: psl:Psta_4304 proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Cofactor-independent phosphoglycerate mutase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; PFAM: Metalloenzyme superfamily; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archae [...]
  
     0.435
Isop_2854
RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627: IPR013249: IPR014284; KEGG: psl:Psta_0222 RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; manually curated; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family.
       0.414
Isop_2856
Protein of unknown function DUF1549; InterPro IPR011444; KEGG: sus:Acid_1145 hypothetical protein; PFAM: protein of unknown function DUF1549; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1549); Protein of unknown function (DUF1553).
       0.403
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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