STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_2871(2Fe-2S)-binding domain-containing protein; COGs: COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS/CutS homologs; InterProIPR001041: IPR017909: IPR006058: IPR019546: IPR 002888: IPR006311; KEGG: sus:Acid_2419 2Fe-2S iron-sulfur cluster binding domain-containing protein; PFAM: [2Fe-2S]-binding domain-containing protein; ferredoxin; Twin-arginine translocation pathway, signal sequence, subgroup; SPTR: (2Fe-2S)-binding domain protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; [2Fe-2S] binding domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence. (220 aa)    
Predicted Functional Partners:
Isop_2869
Molybdopterin dehydrogenase FAD-binding protein; COGs: COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM/CutM homologs; InterPro IPR016166: IPR002346; KEGG: sus:Acid_2421 molybdopterin dehydrogenase, FAD-binding; PFAM: molybdopterin dehydrogenase FAD-binding; SPTR: Molybdopterin dehydrogenase, FAD-binding; PFAM: FAD binding domain in molybdopterin dehydrogenase; CO dehydrogenase flavoprotein C-terminal domain; TIGRFAM: 4-hydroxybenzoyl-CoA reductase, beta subunit.
 0.999
Isop_2870
Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein; COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR000674: IPR008274; KEGG: sus:Acid_2420 xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; SPTR: Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b [...]
 
 0.999
Isop_3633
Amidohydrolase; COGs: COG0402 Cytosine deaminase and related metal-dependent hydrolase; InterPro IPR006680; KEGG: hoh:Hoch_5972 guanine deaminase; PFAM: amidohydrolase; SPTR: Guanine deaminase; PFAM: Amidohydrolase family; TIGRFAM: guanine deaminase.
 
 
 0.951
Isop_0275
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
     
  0.900
Isop_1489
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
     
  0.900
Isop_1836
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR005904; KEGG: psl:Psta_1642 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
  0.900
Isop_1515
Protein of unknown function DUF182; COGs: COG1975 Xanthine and CO dehydrogenase maturation factor XdhC/CoxF family; InterPro IPR003777; KEGG: psl:Psta_3800 protein of unknown function DUF182; PFAM: protein of unknown function DUF182; SPTR: Putative uncharacterized protein; PFAM: XdhC and CoxI family.
 
  
 0.843
Isop_2868
Hypothetical protein.
       0.780
Isop_1516
MobA-like protein; COGs: COG2068 Uncharacterized MobA-related protein; KEGG: psl:Psta_3801 MobA-like protein; SPTR: Uncharacterized MobA-related protein-like protein; PFAM: Uncharacterized protein family UPF0007.
 
  
 0.771
Isop_2867
Alanine racemase domain protein; COGs: COG3616 amino acid aldolase or racemase; InterPro IPR001608; KEGG: psl:Psta_1894 alanine racemase domain protein; PFAM: alanine racemase domain protein; SPTR: D-threonine aldolase, metal-activated pyridoxal enzyme; PFAM: Alanine racemase, N-terminal domain.
       0.419
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.