Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (387 aa)    
Predicted Functional Partners:
selA
L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
 
  
 0.983
Isop_0020
COGs: COG0492 Thioredoxin reductase; InterPro IPR005982: IPR000103: IPR013027: IPR008255; KEGG: acp:A2cp1_4094 thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase.
     
 0.913
Isop_1968
COGs: COG0520 Selenocysteine lyase; InterPro IPR000192: IPR010970; KEGG: ace:Acel_1138 SufS subfamily cysteine desulfurase; PFAM: aminotransferase class V; SPTR: Cysteine desulfurases, SufS subfamily; TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurases, SufS subfamily.
    
 0.907
Isop_3475
COGs: COG3276 Selenocysteine-specific translation elongation factor; InterProIPR005225: IPR004535: IPR000795: IPR004161: IPR 015191; KEGG: afw:Anae109_4150 selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 3; SPTR: Selenocysteine-specific translation elongation factor; TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein; PFAM: Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; Elongation factor SelB, winge [...]
 
   
 0.818
Isop_2922
Protein of unknown function UPF0118; COGs: COG0628 permease; InterPro IPR002549; KEGG: pla:Plav_2158 hypothetical protein; PFAM: protein of unknown function UPF0118; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function DUF20.
       0.773
Isop_0815
Cysteine desulfurase IscS; COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192: IPR016454; KEGG: cre:CHLREDRAFT_191269 cysteine desulfurase; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; PFAM: Aminotransferase class-V.
  
 
 0.667
Isop_2132
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR016454: IPR000192; KEGG: rmr:Rmar_1215 aminotransferase class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Aminotransferase class V; PFAM: Aminotransferase class-V.
  
 
 0.613
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.506
Isop_0783
COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; InterPro IPR017896; KEGG: ote:Oter_3934 Fe-S-cluster-containing hydrogenase components 1-like protein; SPTR: Molybdopterin oxidoreductase, iron-sulfur binding subunit.
     
 0.490
gatC
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family.
       0.409
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (38%) [HD]