Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_2943Peptidase M48 Ste24p; InterPro IPR001915; KEGG: psl:Psta_0022 peptidase M48 Ste24p; PFAM: peptidase M48 Ste24p; SPTR: Peptidase M48 Ste24p; PFAM: Peptidase family M48. (490 aa)    
Predicted Functional Partners:
Isop_2941
KEGG: mar:MAE_56260 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.615
Isop_2942
Sulfatase; COGs: COG3119 Arylsulfatase A; InterPro IPR000917; KEGG: psl:Psta_4602 sulfatase; PFAM: sulfatase; SPTR: Heparan N-sulfatase; PFAM: Sulfatase.
       0.615
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.594
Isop_3584
Cytochrome c assembly protein; COGs: COG0755 ABC-type transport system involved in cytochrome c biogenesis permease component; InterPro IPR002541; KEGG: bba:Bd1606 cytochrome c-type biogenesis protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome C assembly protein; PFAM: Cytochrome C assembly protein.
 
     0.589
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.539
Isop_0543
AAA ATPase central domain protein; COGs: COG0465 ATP-dependent Zn protease; InterPro IPR003959: IPR000642: IPR003593: IPR003960; KEGG: mxa:MXAN_2898 ATP-dependent metalloprotease FtsH; PFAM: AAA ATPase central domain protein; peptidase M41; SMART: AAA ATPase; SPTR: ATP-dependent metalloprotease, FtsH family; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.
   
 0.539
Isop_1853
DnaK-related protein; COGs: COG0443 Molecular chaperone; InterPro IPR001023: IPR018181; KEGG: sfu:Sfum_0343 DnaK-related protein; SPTR: DnaK-related protein; PFAM: DNA-K related protein; Hsp70 protein.
 
 
 0.492
Isop_2940
KEGG: act:ACLA_050540 Rho guanyl nucleotide exchange factor, putative; SPTR: Kyphoscoliosis peptidase.
       0.485
Isop_3434
Metallophosphoesterase; InterPro IPR004843; KEGG: psl:Psta_1609 hypothetical protein; PFAM: metallophosphoesterase; SPTR: Putative uncharacterized protein; PFAM: Calcineurin-like phosphoesterase.
  
 
   0.483
Isop_3000
Band 7 protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107; KEGG: llo:LLO_1401 hypothetical protein, SPFH domain/band 7 family; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Putative uncharacterized protein; PFAM: SPFH domain / Band 7 family.
  
 
 0.467
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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