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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Isop_2948Radical SAM domain protein; COGs: COG0820 Fe-S-cluster redox enzyme; InterPro IPR007197: IPR004383; KEGG: ade:Adeh_4229 ribosomal RNA large subunit methyltransferase N; PFAM: Radical SAM domain protein; SPTR: Probable RNA methyltransferase Adeh_4229; PFAM: Radical SAM superfamily; TIGRFAM: radical SAM enzyme, Cfr family; Belongs to the radical SAM superfamily. RlmN family. (373 aa)    
Predicted Functional Partners:
miaB
RNA modification enzyme, MiaB family; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
 
  
 0.681
rimO
SSU ribosomal protein S12P methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily.
 
  
 0.677
Isop_2369
Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.586
Isop_2331
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR001678; KEGG: shw:Sputw3181_2798 Fmu (Sun) domain-containing protein; PFAM: Fmu (Sun) domain protein; SPTR: NOL1/NOP2/sun family putative RNA methylase; PFAM: NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.585
Isop_0264
Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
 
     0.510
Isop_0754
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.509
Isop_2949
COGs: COG0515 Serine/threonine protein kinase; InterProIPR019734: IPR000719: IPR013026: IPR020635: IPR 002290: IPR008271: IPR017442; KEGG: plm:Plim_3456 serine/threonine protein kinase-related protein; PFAM: Serine/threonine-protein kinase-like domain; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, catalytic domain; Tetratricopeptide repeat; SPTR: Serine/threonine protein kinase-related protein; PFAM: Protein kinase domain.
  
    0.478
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
    0.446
efp
Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
  
  
 0.429
Isop_2851
COGs: COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A); InterProIPR011768: IPR013185: IPR001059: IPR015365: IPR 020599; KEGG: rba:RB12577 translation elongation factor EF-P; PFAM: Elongation factor P; Elongation factor P/YeiP protein; Elongation factor KOW-like domain-containing protein; SPTR: Translation elongation factor EF-P; TIGRFAM: translation elongation factor P; PFAM: Elongation factor P, C-terminal; Elongation factor P (EF-P) KOW-like domain; Elongation factor P (EF-P) OB domain; TIGRFAM: translation elongation factor P.
  
  
 0.415
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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