STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (342 aa)    
Predicted Functional Partners:
fcl
NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
 0.993
Isop_0381
COGs: COG0836 Mannose-1-phosphate guanylyltransferase; InterPro IPR005835: IPR001538; KEGG: ttr:Tter_0486 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II; PRIAM: Mannose-1-phosphate guanylyltransferase; SPTR: Mannose-1-phosphate guanylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase.
 
 
 0.941
Isop_0504
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: chl:Chy400_2903 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family.
 
0.941
Isop_3039
Capsular exopolysaccharide family; COGs: COG0489 ATPase involved in chromosome partitioning; InterPro IPR005702: IPR003856; KEGG: rmr:Rmar_1126 capsular exopolysaccharide family; PFAM: lipopolysaccharide biosynthesis protein; PRIAM: Non-specific protein-tyrosine kinase; SPTR: Capsular exopolysaccharide family; TIGRFAM: capsular exopolysaccharide family; PFAM: Chain length determinant protein; CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: capsular exopolysaccharide family.
  
  
 0.679
Isop_0923
COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR003362; KEGG: cyb:CYB_1783 sugar transferase family protein; PFAM: sugar transferase; SPTR: Bacterial sugar transferase family protein; PFAM: Bacterial sugar transferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase.
  
  
 0.673
Isop_3192
COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR003362; KEGG: gme:Gmet_2031 sugar transferase; PFAM: sugar transferase; SPTR: Sugar transferase, PEP-CTERM system associated; PFAM: Bacterial sugar transferase.
  
  
 0.673
Isop_3129
Capsular exopolysaccharide family; COGs: COG0489 ATPase involved in chromosome partitioning; InterPro IPR005702: IPR003856; KEGG: rce:RC1_4006 succinoglycan biosynthesis transport protein ExoP; PFAM: lipopolysaccharide biosynthesis protein; SPTR: Putative uncharacterized protein; TIGRFAM: capsular exopolysaccharide family; PFAM: Chain length determinant protein; CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: capsular exopolysaccharide family.
  
  
 0.615
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
   0.568
Isop_3042
Eight transmembrane protein EpsH; InterPro IPR013426: IPR019127; KEGG: dvl:Dvul_3054 eight transmembrane protein EpsH; PFAM: Exosortase EpsH-related; SPTR: Eight transmembrane protein EpsH; TIGRFAM: eight transmembrane protein EpsH; PFAM: Transmembrane exosortase (Exosortase_EpsH); TIGRFAM: eight transmembrane protein EpsH (proposed exosortase).
       0.557
Isop_3043
EpsI family protein; InterPro IPR014263; KEGG: dba:Dbac_2581 EpsI family protein; SPTR: EpsI family protein; TIGRFAM: EpsI family protein; PFAM: Protein of unknown function (DUF3485); TIGRFAM: EpsI family protein.
       0.539
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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