STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Isop_3080RNA polymerase, sigma 38 subunit, RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (277 aa)    
Predicted Functional Partners:
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.738
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.715
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
  
 0.707
Isop_3158
Cyclic nucleotide-binding protein; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR017900: IPR018528: IPR018488: IPR002373: IPR 000595: IPR001041: IPR017896; KEGG: sus:Acid_4310 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; ferredoxin; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain.
   
 
 0.695
Isop_1658
COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; InterPro IPR019734: IPR013026: IPR011260: IPR001440; KEGG: psl:Psta_3991 RNA polymerase alpha subunit domain protein; PFAM: RNA polymerase alpha subunit domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SPTR: RNA polymerase alpha subunit domain protein; PFAM: Tetratricopeptide repeat; Bacterial RNA polymerase, alpha chain C terminal domain.
 
 
 0.659
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.651
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.624
Isop_2202
Hypothetical protein; InterPro IPR006162; KEGG: kpe:KPK_A0192 hypothetical protein; SPTR: Membrane protein.
    
   0.591
Isop_2213
Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847: IPR005119; KEGG: psl:Psta_0198 transcriptional regulator, LysR family; PFAM: LysR substrate-binding; regulatory protein LysR; SPTR: Transcriptional regulator, LysR family; PFAM: LysR substrate binding domain; Bacterial regulatory helix-turn-helix protein, lysR family.
    
 
 0.582
Isop_0055
Cyclic nucleotide-binding protein; InterPro IPR000595; KEGG: tcr:504449.30 hypothetical protein; PFAM: cyclic nucleotide-binding; SPTR: Putative uncharacterized protein; PFAM: Cyclic nucleotide-binding domain.
    
 
 0.575
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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