STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_3138GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (284 aa)    
Predicted Functional Partners:
Isop_3137
Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; KEGG: sus:Acid_6318 heat shock protein DnaJ domain-containing protein; PFAM: heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; SPTR: Putative uncharacterized protein; PFAM: DnaJ domain.
 
 
 0.939
Isop_3139
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR018181: IPR001023: IPR013126; KEGG: nhl:Nhal_2517 heat shock protein 70; PFAM: Heat shock protein 70; SPTR: Heat shock protein 70; PFAM: Hsp70 protein.
 
 
 0.886
Isop_2389
Heat shock protein 70 family protein; COGs: COG0443 Molecular chaperone; InterPro IPR018181; KEGG: mxa:MXAN_5322 heat shock protein 70 family protein; SPTR: Heat shock protein 70 family protein; PFAM: Hsp70 protein.
 
 
 0.843
Isop_1853
DnaK-related protein; COGs: COG0443 Molecular chaperone; InterPro IPR001023: IPR018181; KEGG: sfu:Sfum_0343 DnaK-related protein; SPTR: DnaK-related protein; PFAM: DNA-K related protein; Hsp70 protein.
 
 
 0.833
Isop_0076
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR001023: IPR018181: IPR013126; KEGG: cac:CA_C0472 HSP70/DnaK family protein; PFAM: Heat shock protein 70; SPTR: Chaperone protein dnaK; PFAM: Hsp70 protein.
  
 
 0.777
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.777
Isop_1041
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR002035: IPR013126: IPR001023: IPR018181; KEGG: cac:CA_C0473 heat shock protein DnaK; PFAM: Heat shock protein 70; von Willebrand factor type A; SMART: von Willebrand factor type A; SPTR: DnaK protein (Heat shock protein), C-terminal region has VWA type A domain; PFAM: Hsp70 protein; von Willebrand factor type A domain.
  
 
 0.777
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.761
groL-2
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.761
groL-3
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.761
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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