STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
Isop_3171Hypothetical protein; InterPro IPR011761; KEGG: bja:bll8229 hypothetical protein; SPTR: D-alanine--D-alanine ligase; PFAM: D-ala D-ala ligase C-terminus. (348 aa)    
Predicted Functional Partners:
Isop_3399
KEGG: psl:Psta_2947 hypothetical protein; SPTR: Putative uncharacterized protein.
  
  
 0.764
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
  
  
 0.556
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
  
  
 0.511
Isop_0185
COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterPro IPR018044: IPR001466: IPR002477: IPR001967; KEGG: psl:Psta_1647 peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Peptidoglycan-binding domain 1 protein; beta-lactamase; SPTR: Peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; PFAM: Putative peptidoglycan binding domain; D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.
  
  
 0.510
Isop_1602
KEGG: psp:PSPPH_1090 ribosomal subunit interface protein, putative; SPTR: Ribosomal subunit interface protein, putative; PFAM: Sigma 54 modulation protein / S30EA ribosomal protein.
  
  
 0.502
Isop_3619
Beta-lactamase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
     
 0.488
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.458
lpxC
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily.
     
 0.453
lysS
COGs: COG1190 Lysyl-tRNA synthetase (class II); InterProIPR006195: IPR004365: IPR004364: IPR018149: IPR 002313; KEGG: psl:Psta_0647 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; SPTR: Lysyl-tRNA synthetase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.408
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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