Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_3242Cobalamin synthesis protein P47K; COGs: COG0523 Putative GTPase (G3E family); InterPro IPR003495: IPR011629; KEGG: rrs:RoseRS_3105 cobalamin synthesis protein, P47K; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; SPTR: Cobalamin synthesis protein, P47K; PFAM: CobW/HypB/UreG, nucleotide-binding domain; Cobalamin synthesis protein cobW C-terminal domain. (443 aa)    
Predicted Functional Partners:
Isop_3243
ABC transporter related protein; COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR017871: IPR003593: IPR003439; KEGG: gvi:glr3104 ABC transporter ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Glr3104 protein; PFAM: ABC transporter.
 
     0.748
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
    
 
 0.688
rpsZ
SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
  
 
 0.667
Isop_1063
Periplasmic solute binding protein; COGs: COG0803 ABC-type metal ion transport system periplasmic component/surface adhesin; InterPro IPR006311: IPR006127: IPR006128: IPR006129; KEGG: sth:STH1506 ABC transporter permease protein; PFAM: periplasmic solute binding protein; SPTR: ABC transporter permease protein; PFAM: Periplasmic solute binding protein family; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.649
Isop_3675
Transcriptional regulator, TraR/DksA family; COGs: COG1734 DnaK suppressor protein; InterPro IPR020458: IPR000962; KEGG: psl:Psta_2164 transcriptional regulator, TraR/DksA family; SPTR: Transcriptional regulator, TraR/DksA family; PFAM: Prokaryotic dksA/traR C4-type zinc finger.
  
  
 0.603
rpmB
Ribosomal protein L28; InterPro IPR001383; KEGG: psl:Psta_4214 ribosomal protein L28; PFAM: ribosomal protein L28; SPTR: 50S ribosomal protein L28; TIGRFAM: ribosomal protein L28; PFAM: Ribosomal L28 family; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
  
  
 0.568
Isop_3244
Hypothetical protein; COGs: COG1277 ABC-type transport system involved in multi-copper enzyme maturation permease component; KEGG: gvi:glr3106 hypothetical protein; SPTR: Glr3106 protein; PFAM: Domain of unknown function (DUF3526).
 
     0.544
Isop_3245
Hypothetical protein; COGs: COG1277 ABC-type transport system involved in multi-copper enzyme maturation permease component; KEGG: gvi:glr3105 hypothetical protein; SPTR: Glr3105 protein; PFAM: Domain of unknown function (DUF3526).
 
     0.458
Isop_3631
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterProIPR012818: IPR014008: IPR006342: IPR006365: IPR 000878: IPR007848; KEGG: psl:Psta_2973 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; methyltransferase small; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subun [...]
     
 0.437
rpmG
LSU ribosomal protein L33P; InterPro IPR001705; KEGG: plm:Plim_0436 ribosomal protein L33; PFAM: ribosomal protein L33; SPTR: 50S ribosomal protein L33; TIGRFAM: ribosomal protein L33; PFAM: Ribosomal protein L33; TIGRFAM: ribosomal protein L33, bacterial type; Belongs to the bacterial ribosomal protein bL33 family.
  
  
 0.422
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.