Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_3269SSS sodium solute transporter superfamily; COGs: COG0591 Na+/proline symporter; InterPro IPR019900: IPR001734; KEGG: rba:RB7512 putative integral membrane transport protein; PFAM: Na+/solute symporter; SPTR: Putative integral membrane transport protein; TIGRFAM: SSS sodium solute transporter superfamily; PFAM: Sodium:solute symporter family; TIGRFAM: transporter, SSS family; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (492 aa)    
Predicted Functional Partners:
Isop_3270
COGs: COG3876 conserved hypothetical protein; InterPro IPR001466: IPR008302; KEGG: aba:Acid345_2615 hypothetical protein; PFAM: Uncharacterised conserved protein UCP016719; beta-lactamase; SPTR: Uncharacterised conserved protein UCP016719; PFAM: Beta-lactamase; Protein of unknown function (DUF1343).
     0.838
Isop_0123
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR002872: IPR015590; KEGG: psl:Psta_0870 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; SPTR: 1-pyrroline-5 carboxylate dehydrogenase; PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Belongs to the aldehyde dehydrogenase family.
  
  
 0.639
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
  
 0.620
Isop_1362
SSS sodium solute transporter superfamily; COGs: COG4145 Na+/panthothenate symporter; InterPro IPR001734: IPR019900; KEGG: psl:Psta_2785 Na+/solute symporter; PFAM: Na+/solute symporter; SPTR: Na+/solute symporter; TIGRFAM: SSS sodium solute transporter superfamily; PFAM: Sodium:solute symporter family; TIGRFAM: transporter, SSS family; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
     0.611
Isop_3271
COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358: IPR000014: IPR001610: IPR003661: IPR 003594: IPR001789: IPR005467: IPR000700: IPR008207: IPR013767; KEGG: psl:Psta_1412 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing protein; response regulator receiver; SPTR: PAS/PAC sensor hybrid h [...]
  
  
 0.579
Isop_3268
Maf protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
       0.505
Isop_1972
COGs: COG0642 Signal transduction histidine kinase; InterProIPR013655: IPR013767: IPR003661: IPR003594: IPR 001789: IPR008207: IPR000014: IPR004358: IPR000896: IPR005467; KEGG: rba:RB159 sensory transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; Hpt domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensory transduction histidine k [...]
  
  
 0.440
Isop_3267
Glycosyl hydrolase family 88; InterPro IPR010905; KEGG: psl:Psta_0036 glycosyl hydrolase family 88; PFAM: glycosyl hydrolase family 88; SPTR: Glucuronyl hydrolase, putative; PFAM: Glycosyl Hydrolase Family 88.
       0.417
Isop_1742
Polar amino acid ABC transporter, inner membrane subunit; COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR000515: IPR001638: IPR010065; KEGG: tai:Taci_0574 polar amino acid ABC transporter, inner membrane subunit; PFAM: extracellular solute-binding protein family 3; binding-protein-dependent transport systems inner membrane component; SMART: extracellular solute-binding protein family 3; SPTR: Polar amino acid ABC transporter, inner membrane subunit; TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent tra [...]
   
 
 0.403
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.