STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_3272Mannose-6-phosphate isomerase, type 1; COGs: COG1482 Phosphomannose isomerase; InterPro IPR001917: IPR001250: IPR014628; KEGG: psl:Psta_4651 mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; PRIAM: Mannose-6-phosphate isomerase; SPTR: Mannose-6-phosphate isomerase, class I; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: Phosphomannose isomerase type I; TIGRFAM: mannose-6-phosphate isomerase, class I. (332 aa)    
Predicted Functional Partners:
Isop_0011
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005841: IPR016066: IPR005844: IPR005845; KEGG: rba:RB6061 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; SPTR: Phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, al [...]
 
 
 0.938
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR018189: IPR000169: IPR001672; KEGG: mxa:MXAN_6908 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
  
 
 0.917
pfp
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
  
 0.916
Isop_0492
COGs: COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; InterPro IPR006148; KEGG: gym:GYMC10_1212 glucosamine-6-phosphate deaminase; PFAM: glucosamine/galactosamine-6-phosphate isomerase; SPTR: Glucosamine/galactosamine-6-phosphate isomerase; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.
  
  
 0.915
Isop_0085
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841: IPR005844: IPR005845: IPR005846: IPR 005843; KEGG: rba:RB9832 phosphomannomutase (pmm); PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase (Pmm); PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, [...]
  
 
 0.912
glmS
Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
     
 0.912
Isop_1077
COGs: COG0205 6-phosphofructokinase; InterPro IPR011403: IPR000023; KEGG: psl:Psta_4392 6-phosphofructokinase; PFAM: phosphofructokinase; SPTR: 6-phosphofructokinase; PFAM: Phosphofructokinase.
     
 0.903
fbp
Inositol phosphatase/fructose-16-bisphosphatase; COGs: COG0158 Fructose-1 6-bisphosphatase; InterPro IPR000146; KEGG: amr:AM1_6321 fructose-1,6-bisphosphatase; PFAM: Inositol phosphatase/fructose-16-bisphosphatase; SPTR: Fructose-1,6-bisphosphatase class 1 2; PFAM: Fructose-1-6-bisphosphatase.
     
 0.903
Isop_1420
InterPro IPR006148; KEGG: plm:Plim_2730 glucosamine/galactosamine-6-phosphate isomerase; PFAM: glucosamine/galactosamine-6-phosphate isomerase; SPTR: Glucosamine-6-phosphate isomerase, putative; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.
     
 0.903
Isop_2595
COGs: COG0205 6-phosphofructokinase; InterPro IPR000023; KEGG: plm:Plim_2681 phosphofructokinase; PFAM: phosphofructokinase; SPTR: 6-phosphofructokinase I; PFAM: Phosphofructokinase.
     
 0.903
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.