STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Isop_3286COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: plm:Plim_2611 biotin/lipoate A/B protein ligase; PFAM: biotin/lipoate A/B protein ligase; SPTR: Probable lipoate-protein ligase A-like protein; PFAM: Biotin/lipoate A/B protein ligase family. (292 aa)    
Predicted Functional Partners:
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
 
 0.917
Isop_1354
COGs: COG0321 Lipoate-protein ligase B; InterPro IPR004143; KEGG: plm:Plim_3383 lipoate-protein ligase B-like protein; PFAM: biotin/lipoate A/B protein ligase; SPTR: Lipoate-protein ligase B; TIGRFAM: lipoate-protein ligase B.
   
 0.914
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.818
Isop_3257
KEGG: smd:Smed_1270 hypothetical protein; SPTR: Putative uncharacterized protein.
 
 0.506
Isop_2480
KEGG: plm:Plim_1979 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.424
Isop_0045
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 0.423
Isop_3285
Hypothetical protein; KEGG: cat:CA2559_03365 glutamyl-tRNA synthetase; SPTR: Putative uncharacterized protein.
       0.420
Isop_0416
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: sth:STH413 pyruvate dehydrogenase E2; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Pyruvate dehydrogenase E2; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
  
 0.414
Isop_0843
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: ace:Acel_0588 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases [...]
  
 0.414
Isop_0904
InterPro IPR000089; KEGG: fre:Franean1_7269 dehydrogenase catalytic domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Probable hydrolase; PFAM: Biotin-requiring enzyme.
  
 0.414
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.