STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_3300uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR003043: IPR006366: IPR000878: IPR003754; KEGG: gme:Gmet_3235 uroporphyrinogen-III synthase/uroporphyrinogen-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. (530 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
Isop_3697
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: gsu:GSU3282 siroheme synthase; SPTR: Siroheme synthase, N-terminal domain protein; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain.
 
 
 0.992
Isop_2023
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: msl:Msil_0420 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.986
cysC
Sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
 
  
 0.959
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.956
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.931
cysH
Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.902
Isop_1056
COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117: IPR006067: IPR006066; KEGG: psl:Psta_1330 sulfite reductase (NADPH); PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; PRIAM: Sulfite reductase (NADPH); SPTR: Sulfite reductase; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: ferredoxin-sulfite reductase.
 
  
 0.902
Isop_0994
Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: plm:Plim_2903 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX.
 
  
 0.878
Isop_3584
Cytochrome c assembly protein; COGs: COG0755 ABC-type transport system involved in cytochrome c biogenesis permease component; InterPro IPR002541; KEGG: bba:Bd1606 cytochrome c-type biogenesis protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome C assembly protein; PFAM: Cytochrome C assembly protein.
  
  
 0.866
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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