STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_3339Dehydratase, YjhG/YagF family; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR017798: IPR000581: IPR020558; KEGG: psl:Psta_2493 dehydratase, YjhG/YagF family; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dehydratase, YjhG/YagF family; TIGRFAM: dehydratase, YjhG/YagF family; PFAM: Dehydratase family; TIGRFAM: probable dehydratase, YjhG/YagF family; Belongs to the IlvD/Edd family. (674 aa)    
Predicted Functional Partners:
Isop_2260
COGs: COG3970 Fumarylacetoacetate (FAA) hydrolase family protein; InterPro IPR002529; KEGG: scl:sce8243 fumarylacetoacetase family protein; PFAM: fumarylacetoacetate (FAA) hydrolase; SPTR: Fumarylacetoacetase family protein; PFAM: Fumarylacetoacetate (FAA) hydrolase family.
 
  
 0.934
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.889
Isop_0284
COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789: IPR002912: IPR019455; KEGG: psl:Psta_4688 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit.
 
 
 0.843
Isop_0933
Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012846: IPR012001: IPR012000: IPR011766: IPR 000399; KEGG: psl:Psta_1779 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphat [...]
 
 
 0.791
Isop_3340
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: rba:RB10858 oxidoreductase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family.
   
   0.762
Isop_3461
Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG1171 Threonine dehydratase; InterPro IPR001926: IPR000634; KEGG: scl:sce3847 putative serine/threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Putative serine/threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme.
 
 
 0.760
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.759
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.745
Isop_2596
COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR000399: IPR012001: IPR012000: IPR011766; KEGG: rce:RC1_0235 acetolactate synthase large subunit, putative; PFAM: thiamine pyrophosphate central domain-containing protein; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate enzyme-like TPP binding protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
 
 
 0.740
Isop_2214
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
  
  
 0.688
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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