STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_3341Peptidase M48 Ste24p; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: bge:BC1002_5469 peptidase M48 Ste24p; PFAM: peptidase M48 Ste24p; SPTR: Peptidase M48 Ste24p; PFAM: Peptidase family M48. (689 aa)    
Predicted Functional Partners:
Isop_3342
LemA family protein; COGs: COG1704 conserved hypothetical protein; InterPro IPR007156; KEGG: dol:Dole_1528 LemA family protein; PFAM: LemA family protein; SPTR: LemA family protein; PFAM: LemA family.
 
    0.872
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.594
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.539
Isop_0543
AAA ATPase central domain protein; COGs: COG0465 ATP-dependent Zn protease; InterPro IPR003959: IPR000642: IPR003593: IPR003960; KEGG: mxa:MXAN_2898 ATP-dependent metalloprotease FtsH; PFAM: AAA ATPase central domain protein; peptidase M41; SMART: AAA ATPase; SPTR: ATP-dependent metalloprotease, FtsH family; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.
   
 0.539
Isop_3264
KEGG: mar:MAE_47620 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Dynamin family.
    
 0.461
Isop_1528
Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0369 Sulfite reductase alpha subunit (flavoprotein); InterProIPR017927: IPR001709: IPR012146: IPR008333: IPR 001433; KEGG: gvi:gvip312 ferredoxin--NADP+ reductase; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: Ferredoxin--NADP+ reductase; manually curated; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain.
    
   0.412
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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