Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Isop_3375Helicase domain protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014021: IPR001650: IPR000330: IPR014001; KEGG: sme:SMc02152 putative helicase protein; PFAM: helicase domain protein; SNF2-related protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: Helicase-DNA-binding protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain. (1166 aa)    
Predicted Functional Partners:
Isop_3374
Protein of unknown function DUF1156; COGs: COG1743 Adenine-specific DNA methylase containing a Zn-ribbon; InterPro IPR009537: IPR012327; KEGG: sme:SMc02154 hypothetical protein; PFAM: protein of unknown function DUF1156; D12 class N6 adenine-specific DNA methyltransferase; SPTR: Putative uncharacterized protein; PFAM: D12 class N6 adenine-specific DNA methyltransferase; Transposase IS200 like; Protein of unknown function (DUF1156).
 
     0.955
Isop_3371
Hypothetical protein; COGs: COG1483 ATPase (AAA+ superfamily); KEGG: sme:SMc02155 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF499).
 
     0.945
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
  
 0.774
Isop_3372
KEGG: mar:MAE_40430 hypothetical protein; SPTR: Genome sequencing data, contig C279; PFAM: Protein of unknown function DUF82.
       0.773
Isop_3373
Protein of unknown function DUF433; COGs: COG2442 conserved hypothetical protein; InterPro IPR007367; KEGG: cyc:PCC7424_3561 protein of unknown function DUF433; PFAM: protein of unknown function DUF433; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF433).
       0.773
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.718
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.715
Isop_2145
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.715
Isop_1517
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterProIPR014021: IPR001650: IPR014014: IPR000629: IPR 014001: IPR011545; KEGG: psl:Psta_1620 DEAD/DEAH box helicase domain protein; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
  
 0.679
Isop_2908
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: cag:Cagg_1601 histone deacetylase superfamily; PFAM: histone deacetylase superfamily; PRIAM: Histone deacetylase; SPTR: Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
    
 0.678
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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