STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
csrA-5Carbon storage regulator, CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (79 aa)    
Predicted Functional Partners:
fliW
Protein of unknown function DUF180; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
 
 
 0.934
csrA-4
Carbon storage regulator, CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
  
     0.765
Isop_3688
CheW protein; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR019734: IPR002545: IPR013026; KEGG: cel:ZK84.1 hypothetical protein; PFAM: CheW domain protein; SMART: CheW domain protein; Tetratricopeptide repeat; SPTR: Putative uncharacterized protein; PFAM: CheW-like domain.
 
  
 0.527
Isop_1367
RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.508
Isop_1369
Type III secretion FHIPEP protein; COGs: COG1298 Flagellar biosynthesis pathway component FlhA; InterPro IPR001712; KEGG: plm:Plim_1138 flagellar biosynthesis protein FlhA; PFAM: type III secretion FHIPEP protein; SPTR: Flagella-associated protein; PFAM: FHIPEP family; TIGRFAM: flagellar biosynthesis protein FlhA.
 
  
 0.468
Isop_2319
Type III secretion system inner membrane P protein; COGs: COG1338 Flagellar biosynthesis pathway component FliP; InterPro IPR005838; KEGG: adg:Adeg_2033 flagellar biosynthetic protein FliP; PFAM: type III secretion system inner membrane P protein; SPTR: Flagellar biosynthetic protein FliP; PFAM: FliP family.
 
  
 0.442
Isop_3380
InterPro IPR014284: IPR007627; KEGG: zpr:ZPR_2352 RNA polymerase ECF-type sigma factor; PFAM: sigma-70 region 2 domain protein; SPTR: RNA polymerase sigma factor/ECF subfamily (Sigma-70); TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family.
       0.440
Isop_3690
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207: IPR003594: IPR002545: IPR001789: IPR 005467: IPR004105: IPR004358; KEGG: aeh:Mlg_0359 CheA signal transduction histidine kinases; PFAM: response regulator receiver; CheW domain protein; ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; SMART: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein; SPTR: CheA signal transduction histidine kin [...]
 
  
 0.401
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.