STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_3509FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027: IPR004099: IPR000815: IPR012999; KEGG: gvi:gll0564 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Mercuric reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. (514 aa)    
Predicted Functional Partners:
Isop_3508
COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; InterPro IPR001173; KEGG: srm:SRM_01382 N-acetylglucosaminyltransferase; PFAM: glycosyl transferase family 2; SPTR: Glycosyl transferase family 2; PFAM: Glycosyl transferase family 2.
 
     0.869
Isop_3507
Hypothetical protein; COGs: COG0535 Fe-S oxidoreductase; KEGG: nde:NIDE3701 hypothetical protein; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily; Protein of unknown function (DUF3641).
 
   
 0.860
Isop_0417
COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475: IPR005476; KEGG: mxa:MXAN_4565 2-oxoisovalerate dehydrogenase complex, E1 component, beta subunit; PFAM: Transketolase domain-containing protein; Transketolase central region; PRIAM: Pyruvate dehydrogenase (acetyl-transferring); SPTR: 2-oxoisovalerate dehydrogenase complex, E1 component, beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
 
 0.854
Isop_0842
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.854
Isop_0416
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: sth:STH413 pyruvate dehydrogenase E2; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Pyruvate dehydrogenase E2; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
 
 0.850
Isop_0843
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR003016; KEGG: ace:Acel_0588 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases [...]
 0.847
Isop_0045
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.824
Isop_0044
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603: IPR001017: IPR005475; KEGG: sfu:Sfum_3547 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SPTR: 2-oxoglutarate dehydrogenase, E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
  
 0.792
Isop_0904
InterPro IPR000089; KEGG: fre:Franean1_7269 dehydrogenase catalytic domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Probable hydrolase; PFAM: Biotin-requiring enzyme.
  
 0.782
Isop_3257
KEGG: smd:Smed_1270 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 0.782
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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