STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Isop_3531Histidine biosynthesis protein; COGs: COG1411 Uncharacterized protein related to proFAR isomerase (HisA); InterPro IPR006062; KEGG: vap:Vapar_3068 histidine biosynthesis protein; PFAM: histidine biosynthesis protein; SPTR: HisA/HisF family protein, putative; PFAM: Histidine biosynthesis protein. (239 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
     
 0.913
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: msl:Msil_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phospho [...]
     
 0.913
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
     
  0.900
Isop_1717
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
     
  0.900
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
     
  0.900
Isop_3532
Protein of unknown function DUF201; InterPro IPR011761: IPR003806; KEGG: mpt:Mpe_A2621 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: Putative uncharacterized protein; PFAM: ATP-grasp domain.
 
     0.900
Isop_3533
H4MPT-linked C1 transfer pathway protein; COGs: COG1548 transcriptional regulator/sugar kinase; InterPro IPR002756: IPR002821; KEGG: plm:Plim_0257 H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; SPTR: Conserved protein; TIGRFAM: H4MPT-linked C1 transfer pathway protein; manually curated; PFAM: Hydantoinase/oxoprolinase; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein.
 
     0.860
Isop_3534
COGs: COG2054 Uncharacterized kinase related to aspartokinase uridylate kinase; InterPro IPR001048; KEGG: psl:Psta_3593 aspartate/glutamate/uridylate kinase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: Aspartate/glutamate/uridylate kinase; PFAM: Amino acid kinase family.
 
     0.859
Isop_0524
COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR013108: IPR012027; KEGG: psl:Psta_0063 formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; SPTR: Formylmethanofuran dehydrogenase subunit A; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A.
 
   
 0.797
Isop_0326
COGs: COG2218 Formylmethanofuran dehydrogenase subunit C; InterPro IPR002489: IPR017550; KEGG: nhl:Nhal_0012 formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein; PRIAM: Formylmethanofuran dehydrogenase; SPTR: Formylmethanofuran dehydrogenase subunit C; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C.
 
   
 0.792
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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