Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (201 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.919
Isop_2071
DNA methylase N-4/N-6 domain protein; COGs: COG0863 DNA modification methylase; InterPro IPR002941: IPR001091: IPR002052; KEGG: chl:Chy400_0713 DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase N-4/N-6 domain protein; SPTR: DNA methylase; PFAM: DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family.
    
 0.802
Isop_1312
COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963: IPR001126; KEGG: psl:Psta_3727 DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; PRIAM: DNA-directed DNA polymerase; SPTR: DNA-directed DNA polymerase; PFAM: impB/mucB/samB family.
  
 
 0.681
Isop_2126
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.564
Isop_0952
Exodeoxyribonuclease V; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR014016: IPR014017: IPR000212; KEGG: plm:Plim_1377 exodeoxyribonuclease V; PFAM: UvrD/REP helicase; PRIAM: Exodeoxyribonuclease V; SPTR: UvrD/REP helicase; PFAM: UvrD/REP helicase.
  
   
 0.499
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
   
 0.479
Isop_0388
DNA methylase N-4/N-6 domain protein; COGs: COG0863 DNA modification methylase; InterPro IPR002941: IPR002052: IPR001091; KEGG: psl:Psta_0519 DNA methylase N-4/N-6 domain protein; PFAM: DNA methylase N-4/N-6 domain protein; SPTR: Adenine-specific methyltransferase; PFAM: DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family.
    
 0.429
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
  
  
 0.403
Isop_1086
Competence/damage-inducible protein CinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135: IPR008136: IPR001453; KEGG: rxy:Rxyl_2558 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofacto [...]
     
 0.400
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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