Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_3675Transcriptional regulator, TraR/DksA family; COGs: COG1734 DnaK suppressor protein; InterPro IPR020458: IPR000962; KEGG: psl:Psta_2164 transcriptional regulator, TraR/DksA family; SPTR: Transcriptional regulator, TraR/DksA family; PFAM: Prokaryotic dksA/traR C4-type zinc finger. (160 aa)    
Predicted Functional Partners:
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.776
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.775
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.666
Isop_1658
COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; InterPro IPR019734: IPR013026: IPR011260: IPR001440; KEGG: psl:Psta_3991 RNA polymerase alpha subunit domain protein; PFAM: RNA polymerase alpha subunit domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SPTR: RNA polymerase alpha subunit domain protein; PFAM: Tetratricopeptide repeat; Bacterial RNA polymerase, alpha chain C terminal domain.
   
 
 0.617
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.617
Isop_1212
Cobalamin synthesis protein P47K; COGs: COG0523 Putative GTPase (G3E family); InterPro IPR003495: IPR011629; KEGG: rme:Rmet_1098 cobalamin synthesis protein P47K; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; SPTR: Cobalamin synthesis protein/P47K; PFAM: Cobalamin synthesis protein cobW C-terminal domain; CobW/HypB/UreG, nucleotide-binding domain.
  
  
 0.603
Isop_3242
Cobalamin synthesis protein P47K; COGs: COG0523 Putative GTPase (G3E family); InterPro IPR003495: IPR011629; KEGG: rrs:RoseRS_3105 cobalamin synthesis protein, P47K; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; SPTR: Cobalamin synthesis protein, P47K; PFAM: CobW/HypB/UreG, nucleotide-binding domain; Cobalamin synthesis protein cobW C-terminal domain.
  
  
 0.603
rplU
LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
  
 0.541
Isop_3037
Protein of unknown function DUF164; COGs: COG1579 Zn-ribbon protein possibly nucleic acid-binding; InterPro IPR003743; KEGG: plm:Plim_0030 protein of unknown function DUF164; PFAM: protein of unknown function DUF164; SPTR: Putative uncharacterized protein; PFAM: Putative zinc ribbon domain.
  
     0.500
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.495
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.