node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGG89771.1 | EGG89772.1 | HMPREF0491_00901 | HMPREF0491_00902 | Hypothetical protein. | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.992 |
EGG89771.1 | EGG90810.1 | HMPREF0491_00901 | HMPREF0491_02666 | Hypothetical protein. | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.963 |
EGG89771.1 | EGG91757.1 | HMPREF0491_00901 | HMPREF0491_01884 | Hypothetical protein. | Hypothetical protein. | 0.501 |
EGG89771.1 | glyA | HMPREF0491_00901 | HMPREF0491_01701 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
EGG89771.1 | guaA | HMPREF0491_00901 | HMPREF0491_01718 | Hypothetical protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.986 |
EGG89771.1 | guaB | HMPREF0491_00901 | HMPREF0491_01882 | Hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.697 |
EGG89771.1 | metG | HMPREF0491_00901 | HMPREF0491_00699 | Hypothetical protein. | Hypothetical protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.843 |
EGG89771.1 | polA | HMPREF0491_00901 | HMPREF0491_02126 | Hypothetical protein. | Hypothetical protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.989 |
EGG89771.1 | prmC | HMPREF0491_00901 | HMPREF0491_00652 | Hypothetical protein. | protein-(glutamine-N5) methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.944 |
EGG89771.1 | secF | HMPREF0491_00901 | HMPREF0491_00906 | Hypothetical protein. | Hypothetical protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.992 |
EGG89772.1 | EGG89771.1 | HMPREF0491_00902 | HMPREF0491_00901 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein. | 0.992 |
EGG89772.1 | EGG90810.1 | HMPREF0491_00902 | HMPREF0491_02666 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.975 |
EGG89772.1 | EGG91757.1 | HMPREF0491_00902 | HMPREF0491_01884 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein. | 0.980 |
EGG89772.1 | glyA | HMPREF0491_00902 | HMPREF0491_01701 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.992 |
EGG89772.1 | guaA | HMPREF0491_00902 | HMPREF0491_01718 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.983 |
EGG89772.1 | guaB | HMPREF0491_00902 | HMPREF0491_01882 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.983 |
EGG89772.1 | metG | HMPREF0491_00902 | HMPREF0491_00699 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.983 |
EGG89772.1 | polA | HMPREF0491_00902 | HMPREF0491_02126 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.980 |
EGG89772.1 | prmC | HMPREF0491_00902 | HMPREF0491_00652 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | protein-(glutamine-N5) methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.997 |
EGG89772.1 | secF | HMPREF0491_00902 | HMPREF0491_00906 | Hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Hypothetical protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.992 |