STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.975
EEU30874.1
ImpB/MucB/SamB family protein.
 
 
 0.839
EEU30862.1
ImpB/MucB/SamB family protein.
  
 
 0.811
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
      
 0.758
EEU30672.1
Hypothetical protein.
  
  
 0.733
dinG
Putative DnaQ family exonuclease/DinG family helicase; 3'-5' exonuclease.
  
  
 0.705
cinA
Competence/damage-inducible domain protein CinA; Belongs to the CinA family.
     
 0.700
EEU30155.1
biotin--[acetyl-CoA-carboxylase] ligase.
     
 0.693
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
  
  
 0.672
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.667
Your Current Organism:
Lactobacillus coleohominis
NCBI taxonomy Id: 575594
Other names: L. coleohominis 101-4-CHN, Lactobacillus coleohominis 101-4-CHN
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